Genetic polymorphisms and pancreatic cancer risk
نویسندگان
چکیده
منابع مشابه
eNOS Genetic Polymorphisms and Cancer Risk
The association between endothelial nitric oxide synthase (eNOS) polymorphisms (intron 4a/b, -786T>C and 894G>T) and cancer risk remains elusive. In addition, no studies focused on their associations with the risk of breast cancer in Chinese Han population. Thus, a meta-analysis was conducted to determine the relationship between eNOS polymorphisms and cancer risk, and then a case–control study...
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Introduction Recent studies have provided important new insights into the molecular epidemiology and genetics of breast cancer (1–8). Much of this research has focused on the aggregation of breast (and ovarian) cancer within high-risk families, as well as on the role of major cancer susceptibility genes, such as BRCA1, BRCA2, and p53 germ-line mutations (8–10). Putative associations, such as th...
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BACKGROUND Although pancreatic cancer has been extensively studied, few risk factors have been identified, and no validated biomarkers or screening tools exist for early detection in asymptomatic individuals. We present a broad overview of molecular epidemiologic studies that have addressed the relationship between pancreatic cancer risk and genetic polymorphisms in several candidate genes and ...
متن کامل5,10-Methylenetetrahydrofolate reductase polymorphisms and the risk of pancreatic cancer.
To test the hypothesis that 5,10-methylenetetrahydrofolate reductase (MTHFR) polymorphisms modify the risk of pancreatic cancer, we conducted a hospital-based, case-control study involving 347 patients with newly diagnosed pancreatic adenocarcinoma and 348 healthy controls, frequency matched by age, sex, and race. MTHFR polymorphisms were determined using the PCR-RFLP method. Association of the...
متن کاملDNA repair gene polymorphisms and risk of pancreatic cancer.
PURPOSE The current research was undertaken to examine the association between genetic variations in DNA repair and pancreatic cancer risk. EXPERIMENTAL DESIGN We analyzed 9 single nucleotide polymorphisms of 7 DNA repair genes (LIG3, LIG4, OGG1, ATM, POLB, RAD54L, and RECQL) in 734 patients with pancreatic adenocarcinoma and 780 healthy controls using the Taqman method. Information on cigare...
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ژورنال
عنوان ژورنال: Medicine
سال: 2019
ISSN: 0025-7974,1536-5964
DOI: 10.1097/md.0000000000016541